Tesamorelin is a synthetic 44-amino acid peptide analog of growth hormone-releasing hormone (GHRH). CAS Number: 804475-66-9. Molecular weight: approximately 5135.8 Da. It contains the full GHRH(1-44) sequence with a trans-3-hexenoic acid modification at the N-terminus, which enhances its biological stability in research applications.

Modulation of growth hormone (GH) pulsatility and IGF-1 signaling in HIV-associated metabolic models; effects on endogenous GH secretion, insulin sensitivity, inflammatory markers, visceral adipose tissue reduction, and muscle quality in preclinical HIV models (J Clin Endocrinol Metab 2010; J Clin Endocrinol Metab 2011). All findings referenced are from preclinical and in vitro studies. No approved clinical applications exist for this research compound.

For lyophilized form: -20°C or -80°C long-term; short-term refrigeration at 2-8°C or room temperature acceptable for weeks if protected from light and moisture (Peptide Sciences; SB Peptide). Avoid repeated freeze-thaw cycles. Once reconstituted, the solution should be refrigerated at 2-8°C and used within 28 days.

Peptide.co’s Tesamorelin has been verified at 99.7% purity through independent third-party HPLC testing. The current batch (Lot #YPB.279, 10mg) includes a full Certificate of Analysis confirming identity, purity, and peptide content. All COAs are publicly available at coa.peptide.co. Testing covers HPLC purity analysis, mass spectrometry identity confirmation, heavy metals screening (<20 ppb), and microbial limits (TAMC/TYMC: 0 CFU). All products are manufactured in FDA-registered facilities in the United States.

Growth hormone-releasing hormone (GHRH) receptor agonist; binds and stimulates GHRH receptors with potency similar to endogenous GRF, augmenting pulsatile GH secretion and downstream IGF-1 signaling (PubChem; NCATS Inxight Drugs). These mechanisms have been characterized in preclinical models only.

Tesamorelin is supplied as a lyophilized (freeze-dried) powder and must be reconstituted before use in research applications. The standard reconstitution solvent is bacteriostatic water (sterile water containing 0.9% benzyl alcohol). When reconstituting, direct the solvent gently along the inside wall of the vial — do not spray directly onto the lyophilized powder. Allow the peptide to dissolve naturally without shaking or vortexing. For detailed reconstitution volume calculations, use the free Bacteriostatic Water Calculator or Peptide Reconstitution Calculator on Peptide.co.