Ipamorelin is a synthetic pentapeptide (five amino acids: Aib-His-D-2-Nal-D-Phe-Lys-NH2) that acts as a selective growth hormone secretagogue. CAS Number: 170851-70-4. Molecular weight: 711.85 Da. Unlike other GH secretagogues, Ipamorelin shows high selectivity for the ghrelin/GHS receptor without significantly affecting cortisol, prolactin, or ACTH levels in preclinical models.

Growth hormone release from pituitary cells (in vitro rat studies, Eur J Endocrinol 1998); gastric emptying and smooth muscle contractility in postoperative ileus rodent models (J Exp Pharmacol 2012); weight loss inhibition in cisplatin-treated ferrets (Physiol Behav 2024); GH hypersecretion in diabetic mice (J Diabetes Res 2003); reproductive axis in tilapia fish (Anim Reprod Sci 2024) All findings referenced are from preclinical and in vitro studies. No approved clinical applications exist for this research compound.

-20°C or colder, protected from light and moisture for lyophilized form Avoid repeated freeze-thaw cycles. Once reconstituted, the solution should be refrigerated at 2-8°C and used within 28 days.

All products from Peptide.co undergo rigorous third-party laboratory testing to verify identity and purity. Certificates of Analysis (COAs) are available at coa.peptide.co as batches are tested. Testing includes HPLC purity analysis, mass spectrometry identity confirmation, heavy metals screening, and microbial limits testing. All products are manufactured in FDA-registered facilities in the United States.

Selective agonist of the ghrelin/growth hormone secretagogue receptor (GHSR or GHS receptor), mimicking ghrelin to stimulate GH release from pituitary somatotrophs without significant ACTH/cortisol, prolactin, FSH, LH, or TSH elevation These mechanisms have been characterized in preclinical models only.

Ipamorelin is supplied as a lyophilized (freeze-dried) powder and must be reconstituted before use in research applications. The standard reconstitution solvent is bacteriostatic water (sterile water containing 0.9% benzyl alcohol). When reconstituting, direct the solvent gently along the inside wall of the vial — do not spray directly onto the lyophilized powder. Allow the peptide to dissolve naturally without shaking or vortexing. For detailed reconstitution volume calculations, use the free Bacteriostatic Water Calculator or Peptide Reconstitution Calculator on Peptide.co.