Survodutide (BI 456906) is a dual glucagon/GLP-1 receptor agonist peptide. CAS Number: 2375268-82-1. Molecular weight: approximately 4100 Da. Developed by Boehringer Ingelheim, it has been investigated in preclinical research for its dual activity at both glucagon and GLP-1 receptor pathways.

Preclinical obesity/DIO mouse/hamster models (energy expenditure, food intake); MASH/liver fibrosis; hepatocyte cAMP/glycogen synthesis; islet GSIS potentiation; liver transcriptomics (methionine cycle, OXPHOS, cholesterol metabolism, amino acid enzymes) Diabetes 1974-LB, InvivoChem All findings referenced are from preclinical and in vitro studies. No approved clinical applications exist for this research compound.

-20°C powder DC Chemicals Avoid repeated freeze-thaw cycles. Once reconstituted, the solution should be refrigerated at 2-8°C and used within 28 days.

Peptide.co’s Survodutide has been verified at 99.6% purity through independent third-party HPLC testing. The current batch (Lot #YPB.278, 10mg) includes a full Certificate of Analysis confirming identity, purity, and peptide content. All COAs are publicly available at coa.peptide.co. Testing covers HPLC purity analysis, mass spectrometry identity confirmation, heavy metals screening (<20 ppb), and microbial limits (TAMC/TYMC: 0 CFU). All products are manufactured in FDA-registered facilities in the United States.

Dual agonist GCGR (EC50 0.52 nM CHO-K1; gluconeogenesis, glycogenolysis, lipolysis) / GLP-1R (EC50 0.33 nM; reduced intake/emptying); lipidation extends half-life; specific GCGR-driven plasma AA reduction, hepatocyte gene changes vs GLP-1 alone PubChem, Diabetes 1974-LB These mechanisms have been characterized in preclinical models only.

Survodutide is supplied as a lyophilized (freeze-dried) powder and must be reconstituted before use in research applications. The standard reconstitution solvent is bacteriostatic water (sterile water containing 0.9% benzyl alcohol). When reconstituting, direct the solvent gently along the inside wall of the vial — do not spray directly onto the lyophilized powder. Allow the peptide to dissolve naturally without shaking or vortexing. For detailed reconstitution volume calculations, use the free Bacteriostatic Water Calculator or Peptide Reconstitution Calculator on Peptide.co.