Acetyl octapeptide-3, also known as SNAP-8, Ac-Glu-Glu-Met-Gln-Arg-Arg-Ala-Asp-NH2, Acetyl-glutamyl-glutamyl-methionyl-glutaminyl-arginyl-arginyl-alanyl-asparagine, is a 8-amino acid research single peptide. CAS Number: 868844-74-0. Molecular weight: 1073.2 Da. Sequence: Ac-EE-MQ-RR-AD-NH2 (sequence); C42H72N16O15S (formula).

Analytical method development for quantification in cosmetics via LC-MS/MS Ji et al., Journal of Analytical Science and Technology (2020). Limited published preclinical studies identified. All findings referenced are from preclinical and in vitro studies. No approved clinical applications exist for this research compound.

-20°C to -80°C in dry, dark conditions for long-term stability of lyophilized form Avoid repeated freeze-thaw cycles. Once reconstituted, the solution should be refrigerated at 2-8°C and used within 28 days.

Peptide.co’s Snap-8 has been verified at 99.2% purity through independent third-party HPLC testing. The current batch (Lot #YPB.272, 10mg) includes a full Certificate of Analysis confirming identity, purity, and peptide content. All COAs are publicly available at coa.peptide.co. Testing covers HPLC purity analysis, mass spectrometry identity confirmation, heavy metals screening (<20 ppb), and microbial limits (TAMC/TYMC: 0 CFU). All products are manufactured in FDA-registered facilities in the United States.

Mimics N-terminal end of SNAP-25, competes for SNARE complex formation to modulate neurotransmitter exocytosis in cellular models (analogous to related peptides; direct studies primarily on similar hexapeptide) These mechanisms have been characterized in preclinical models only.

Snap-8 is supplied as a lyophilized (freeze-dried) powder and must be reconstituted before use in research applications. The standard reconstitution solvent is bacteriostatic water (sterile water containing 0.9% benzyl alcohol). When reconstituting, direct the solvent gently along the inside wall of the vial — do not spray directly onto the lyophilized powder. Allow the peptide to dissolve naturally without shaking or vortexing. For detailed reconstitution volume calculations, use the free Bacteriostatic Water Calculator or Peptide Reconstitution Calculator on Peptide.co.