4-hydroxy-N-[(E)-naphthalen-2-ylmethylideneamino]benzamide, also known as SLU-PP-332, (E)-4-Hydroxy-N’-(naphthalen-2-ylmethylene)benzohydrazide, is a small molecule research compound. CAS Number: 303760-60-3. Molecular weight: 290.3 Da.

Preclinical studies in mouse models of metabolic syndrome (obesity, increased energy expenditure, fatty acid oxidation, reduced fat mass, improved insulin sensitivity J Pharmacol Exp Ther); exercise endurance enhancement via increased oxidative muscle fibers and mitochondrial function (ACS Chem Biol PMC11584170); heart failure amelioration through enhanced cardiac fatty acid metabolism and mitocho. All findings referenced are from preclinical and in vitro studies. No approved clinical applications exist for this research compound.

Store at -20°C Avoid repeated freeze-thaw cycles. Once reconstituted, the solution should be refrigerated at 2-8°C and used within 28 days.

Peptide.co’s SLU-PP-322 has been verified at 99.3% purity through independent third-party HPLC testing. The current batch (Lot #YPB.243, 5mg) includes a full Certificate of Analysis confirming identity, purity, and peptide content. All COAs are publicly available at coa.peptide.co. Testing covers HPLC purity analysis, mass spectrometry identity confirmation, heavy metals screening (<20 ppb), and microbial limits (TAMC/TYMC: 0 CFU). All products are manufactured in FDA-registered facilities in the United States.

Potent pan-ERR agonist (EC50 ERRα 98 nM, ERRβ 230 nM, ERRγ 430 nM); induces ERRα-dependent acute aerobic exercise genetic program (e.g., DDIT4, Slc25a25), boosts mitochondrial respiration, oxidative phosphorylation, fatty acid oxidation pathways. These mechanisms have been characterized in preclinical models only.

SLU-PP-322 should be handled using standard laboratory safety protocols. Use appropriate personal protective equipment including gloves and eye protection. Work in a clean environment to prevent contamination. Follow your institution’s guidelines for handling research compounds. Refer to the Safety Data Sheet (SDS) for detailed handling instructions.