Semax is a synthetic heptapeptide (seven amino acids) analog of ACTH(4-7) with the sequence Met-Glu-His-Phe-Pro-Gly-Pro. CAS Number: 80714-61-0. Molecular weight: 813.93 Da. Originally developed at the Institute of Molecular Genetics of the Russian Academy of Sciences, it has been studied in preclinical models for its effects on neurotrophic factor expression.

Neuroprotection in ischemia-reperfusion models (Genes 2020); nerve regeneration via neurotrophic factors NGF/NT-3 (SGU 2023); spinal cord injury and lysosomal pathways (Br J Pharmacol 2025); amyloid aggregation inhibition (ACS Chem Neurosci 2022) All findings referenced are from preclinical and in vitro studies. No approved clinical applications exist for this research compound.

−20°C to −80°C, desiccated, protected from light and moisture (Sigma-Aldrich; JPT Peptide Tech; multiple suppliers) Avoid repeated freeze-thaw cycles. Once reconstituted, the solution should be refrigerated at 2-8°C and used within 28 days.

Peptide.co’s Semax has been verified at 99.2% purity through independent third-party HPLC testing. The current batch (Lot #YPB.229, 10mg) includes a full Certificate of Analysis confirming identity, purity, and peptide content. All COAs are publicly available at coa.peptide.co. Testing covers HPLC purity analysis, mass spectrometry identity confirmation, heavy metals screening (<20 ppb), and microbial limits (TAMC/TYMC: 0 CFU). All products are manufactured in FDA-registered facilities in the United States.

Elevates BDNF and TrkB in hippocampus; activates serotonergic/dopaminergic systems; modulates gene expression in inflammation and neurotransmission; chelates Cu(II) inhibiting Aβ aggregation and ROS; inhibits enkephalinases These mechanisms have been characterized in preclinical models only.

Semax is supplied as a lyophilized (freeze-dried) powder and must be reconstituted before use in research applications. The standard reconstitution solvent is bacteriostatic water (sterile water containing 0.9% benzyl alcohol). When reconstituting, direct the solvent gently along the inside wall of the vial — do not spray directly onto the lyophilized powder. Allow the peptide to dissolve naturally without shaking or vortexing. For detailed reconstitution volume calculations, use the free Bacteriostatic Water Calculator or Peptide Reconstitution Calculator on Peptide.co.