Pinealon is a 3-amino acid research peptide. CAS Number: 175175-23-2. Molecular weight: 418.40 Da.

Neuroprotection in models of prenatal hyperhomocysteinemia, Alzheimer’s disease, hypoxia, oxidative stress, and aging-related cognitive decline; prevention of dendritic spine loss; improvement of learning and memory in rat models (e.g., Morris water maze); antioxidant effects in cerebellar neurons. All findings referenced are from preclinical and in vitro studies. No approved clinical applications exist for this research compound.

Store lyophilized form at or below -20°C in a freezer; desiccated to prevent hygroscopic moisture absorption. Avoid repeated freeze-thaw cycles. Once reconstituted, the solution should be refrigerated at 2-8°C and used within 28 days.

Peptide.co’s Pinealon has been verified at 99.5% purity through independent third-party HPLC testing. The current batch (Lot #YPB.273, 20mg) includes a full Certificate of Analysis confirming identity, purity, and peptide content. All COAs are publicly available at coa.peptide.co. Testing covers HPLC purity analysis, mass spectrometry identity confirmation, heavy metals screening (<20 ppb), and microbial limits (TAMC/TYMC: 0 CFU). All products are manufactured in FDA-registered facilities in the United States.

Direct interaction with DNA and histones to modulate gene expression (binding sites in promoters of PPARA, PPARG, SOD2, GPX1, TPH1); suppression of ROS accumulation; delay of ERK1/2 (MAPK/ERK pathway) activation; reduction of apoptosis via lowered caspase-3 and p53; enhancement of antioxidant enzymes SOD2 and GPX1. These mechanisms have been characterized in preclinical models only.

Pinealon is supplied as a lyophilized (freeze-dried) powder and must be reconstituted before use in research applications. The standard reconstitution solvent is bacteriostatic water (sterile water containing 0.9% benzyl alcohol). When reconstituting, direct the solvent gently along the inside wall of the vial — do not spray directly onto the lyophilized powder. Allow the peptide to dissolve naturally without shaking or vortexing. For detailed reconstitution volume calculations, use the free Bacteriostatic Water Calculator or Peptide Reconstitution Calculator on Peptide.co.