Nicotinamide adenine dinucleotide (oxidized form), also known as NAD+, β-NAD, Nadide, Coenzyme I, DPN, is a small molecule research compound. CAS Number: 53-84-9. Molecular weight: 663.4 Da (anhydrous basis).

Redox homeostasis, metabolic regulation (glycolysis, TCA cycle, fatty acid oxidation), DNA repair, epigenetic modification via sirtuins, inflammation modulation, mitochondrial function, aging/longevity mechanisms, ischemia-reperfusion injury protection, neurodegeneration models (Nature Reviews Molecular Cell Biology, Circulation Research, Nature Signal Transduction) All findings referenced are from preclinical and in vitro studies. No approved clinical applications exist for this research compound.

-20°C, desiccated, protected from light Avoid repeated freeze-thaw cycles. Once reconstituted, the solution should be refrigerated at 2-8°C and used within 28 days.

Every batch of NAD+ from Peptide.co undergoes independent third-party HPLC testing. Current verified batches: 500mg batch (Lot #YPB.223): 99.2% purity; 1000mg batch (Lot #YPB.224): 99.5% purity. Full Certificates of Analysis are publicly available at coa.peptide.co, covering HPLC purity, mass spectrometry identity confirmation, heavy metals screening (<20 ppb), and microbial limits (TAMC/TYMC: 0 CFU). All products are manufactured in FDA-registered facilities in the United States.

Redox cofactor in catabolic reactions (NAD+ to NADH); substrate for non-redox enzymes: sirtuin deacylases (deacetylation), PARPs (ADP-ribosylation for DNA repair), CD38/CD157/SARM1 (glycohydrolases producing cADPR/ADPR second messengers) These mechanisms have been characterized in preclinical models only.

NAD+ should be handled using standard laboratory safety protocols. Use appropriate personal protective equipment including gloves and eye protection. Work in a clean environment to prevent contamination. Follow your institution’s guidelines for handling research compounds. Refer to the Safety Data Sheet (SDS) for detailed handling instructions.