Melanotan II is a synthetic cyclic heptapeptide analog of alpha-melanocyte-stimulating hormone (α-MSH). CAS Number: 121062-08-6. Molecular weight: 1024.2 Da. It is a non-selective agonist of melanocortin receptors (MC1R-MC5R) and has been studied in preclinical research for its effects on melanogenesis pathways.

Preclinical studies in melanogenesis, penile erection (Neuroscience, 2006), peripheral nerve regeneration (Eur J Pharmacol, 2003), food intake reduction (Am J Physiol Endocrinol Metab, 2012), memory impairment reversal in high-fat diet models (Biomed Pharmacother, 2023), autistic features in mouse models (PLoS One, 2019), melanoma suppression (Int J Mol Sci, 2020) All findings referenced are from preclinical and in vitro studies. No approved clinical applications exist for this research compound.

Store lyophilized form desiccated at -20°C (stable at room temperature for up to 3 weeks) Avoid repeated freeze-thaw cycles. Once reconstituted, the solution should be refrigerated at 2-8°C and used within 28 days.

Peptide.co’s Melanotan II has been verified at 99.3% purity through independent third-party HPLC testing. The current batch (Lot #YPB.270, 10mg) includes a full Certificate of Analysis confirming identity, purity, and peptide content. All COAs are publicly available at coa.peptide.co. Testing covers HPLC purity analysis, mass spectrometry identity confirmation, heavy metals screening (<20 ppb), and microbial limits (TAMC/TYMC: 0 CFU). All products are manufactured in FDA-registered facilities in the United States.

Non-selective agonist of melanocortin receptors MC1R, MC3R, MC4R, MC5R These mechanisms have been characterized in preclinical models only.

Melanotan II is supplied as a lyophilized (freeze-dried) powder and must be reconstituted before use in research applications. The standard reconstitution solvent is bacteriostatic water (sterile water containing 0.9% benzyl alcohol). When reconstituting, direct the solvent gently along the inside wall of the vial — do not spray directly onto the lyophilized powder. Allow the peptide to dissolve naturally without shaking or vortexing. For detailed reconstitution volume calculations, use the free Bacteriostatic Water Calculator or Peptide Reconstitution Calculator on Peptide.co.