Mazdutide is a dual glucagon-like peptide-1 (GLP-1) and glucagon receptor agonist. CAS Number: 2374982-34-0. Molecular weight: approximately 4194 Da. Developed by Innovent Biologics, it is a recombinant peptide that has been investigated in preclinical research for its activity at both GLP-1R and GCGR pathways.

Glucose control, body weight reduction, increased energy expenditure in wild-type, Gcgr KO, and Glp1r KO mice (eClinicalMedicine 2022 PMC9561728); cognitive function improvement in db/db mice model of T2D (eBioMedicine 2025 PubMed 40479843) All findings referenced are from preclinical and in vitro studies. No approved clinical applications exist for this research compound.

Store at -20°C (lyophilized form, per vendor standards like BroadPharm) Avoid repeated freeze-thaw cycles. Once reconstituted, the solution should be refrigerated at 2-8°C and used within 28 days.

Peptide.co’s Mazdutide has been verified at 99.4% purity through independent third-party HPLC testing. The current batch (Lot #YPB.269, 100mg) includes a full Certificate of Analysis confirming identity, purity, and peptide content. All COAs are publicly available at coa.peptide.co. Testing covers HPLC purity analysis, mass spectrometry identity confirmation, heavy metals screening (<20 ppb), and microbial limits (TAMC/TYMC: 0 CFU). All products are manufactured in FDA-registered facilities in the United States.

Dual agonist of GLP-1 receptor and glucagon receptor; long-acting synthetic oxyntomodulin analogue; potently binds human and mouse GLP-1R and GCGR in vitro These mechanisms have been characterized in preclinical models only.

Mazdutide is supplied as a lyophilized (freeze-dried) powder and must be reconstituted before use in research applications. The standard reconstitution solvent is bacteriostatic water (sterile water containing 0.9% benzyl alcohol). When reconstituting, direct the solvent gently along the inside wall of the vial — do not spray directly onto the lyophilized powder. Allow the peptide to dissolve naturally without shaking or vortexing. For detailed reconstitution volume calculations, use the free Bacteriostatic Water Calculator or Peptide Reconstitution Calculator on Peptide.co.