KissPeptin is a 10-amino acid research peptide. CAS Number: 374675-21-5. Molecular weight: 1302.4 Da.

Preclinical studies in reproduction (GnRH/LH regulation PubMed), tumor metastasis suppression and angiogenesis inhibition (Cancer Res), epilepsy and brain activity (Taylor & Francis), cerebral aneurysms (CNS), chondrocyte senescence (J Biochem Toxicol), blood-brain barrier post-stroke (Clin Exp Pharmacol Physiol), atherosclerosis (JAHA) All findings referenced are from preclinical and in vitro studies. No approved clinical applications exist for this research compound.

Store lyophilized form desiccated at -20°C or colder, protected from light and moisture Avoid repeated freeze-thaw cycles. Once reconstituted, the solution should be refrigerated at 2-8°C and used within 28 days.

Peptide.co’s KissPeptin has been verified at 99.1% purity through independent third-party HPLC testing. The current batch (Lot #YPB.266, 10mg) includes a full Certificate of Analysis confirming identity, purity, and peptide content. All COAs are publicly available at coa.peptide.co. Testing covers HPLC purity analysis, mass spectrometry identity confirmation, heavy metals screening (<20 ppb), and microbial limits (TAMC/TYMC: 0 CFU). All products are manufactured in FDA-registered facilities in the United States.

Binds to KISS1R (GPR54) receptor, a G-protein-coupled receptor, activating downstream pathways including inositol phosphate accumulation; modulates GnRH neurons, inhibits VEGF expression via Sp1 suppression and FAK/Rho GTPase in angiogenesis, interacts with Nrf2 in neuroprotection These mechanisms have been characterized in preclinical models only.

KissPeptin is supplied as a lyophilized (freeze-dried) powder and must be reconstituted before use in research applications. The standard reconstitution solvent is bacteriostatic water (sterile water containing 0.9% benzyl alcohol). When reconstituting, direct the solvent gently along the inside wall of the vial — do not spray directly onto the lyophilized powder. Allow the peptide to dissolve naturally without shaking or vortexing. For detailed reconstitution volume calculations, use the free Bacteriostatic Water Calculator or Peptide Reconstitution Calculator on Peptide.co.