GHK-Cu (Copper Peptide, Glycyl-L-histidyl-L-lysine:copper(II)) is a naturally occurring copper-binding tripeptide consisting of three amino acids: glycine, histidine, and lysine, complexed with a copper(II) ion. CAS Number: 89030-95-5. Molecular weight: 403.9 Da. First identified in human plasma in 1973, it has been studied for its role in tissue remodeling, antioxidant signaling, and collagen synthesis pathways.

Wound healing and tissue remodeling in skin, lung, bone, liver, stomach lining; anti-inflammatory effects; antioxidant activity; nerve outgrowth; collagen/elastin/glycosaminoglycan synthesis; lung protection in ALI/COPD models; anti-cancer activity in cell lines; gene expression modulation in fibroblasts and cancer cells. All findings referenced are from preclinical and in vitro studies. No approved clinical applications exist for this research compound.

Store lyophilized at -20°C or -80°C in sealed vial protected from light and moisture; stable for years. Avoid repeated freeze-thaw cycles. Once reconstituted, the solution should be refrigerated at 2-8°C and used within 28 days.

Every batch of GHK-Cu from Peptide.co undergoes independent third-party HPLC testing. Current verified batches: 50mg batch (Lot #YPB.221): 99.3% purity; 100mg batch (Lot #YPB.222): 99.1% purity. Full Certificates of Analysis are publicly available at coa.peptide.co, covering HPLC purity, mass spectrometry identity confirmation, heavy metals screening (<20 ppb), and microbial limits (TAMC/TYMC: 0 CFU). All products are manufactured in FDA-registered facilities in the United States.

Copper chaperone activating SOD and antioxidant enzymes; modulates gene expression (influences ~4000 genes, resets to healthier state); upregulates collagen/elastin/GAG synthesis genes, TGF-β pathway; downregulates inflammatory genes (NF-κB, TNF-α, IL-6); inhibits iron release from ferritin; promotes angiogenesis via VEGF; stimulates fibroblast/keratinocyte proliferation; proteasome activation for. These mechanisms have been characterized in preclinical models only.

GHK-Cu is supplied as a lyophilized (freeze-dried) powder and must be reconstituted before use in research applications. The standard reconstitution solvent is bacteriostatic water (sterile water containing 0.9% benzyl alcohol). When reconstituting, direct the solvent gently along the inside wall of the vial — do not spray directly onto the lyophilized powder. Allow the peptide to dissolve naturally without shaking or vortexing. For detailed reconstitution volume calculations, use the free Bacteriostatic Water Calculator or Peptide Reconstitution Calculator on Peptide.co.