CJC-1295 No DAC (Modified GRF 1-29) is a 29-amino acid synthetic peptide analog of growth hormone-releasing hormone (GHRH). CAS Number: 863288-34-0. Molecular weight: approximately 3367.9 Da. The ‘No DAC’ designation means it lacks the Drug Affinity Complex, giving it a shorter half-life compared to the DAC variant. It has been studied in preclinical research for its effects on growth hormone secretion.

Growth hormone release and normalization in GHRH knockout mice models (Alba et al., Am J Physiol Endocrinol Metab, 2006 PubMed); somatotroph proliferation (Gautam et al., PNAS, 2009 PMC) All findings referenced are from preclinical and in vitro studies. No approved clinical applications exist for this research compound.

Store lyophilized powder at -20°C or preferably -80°C in a desiccated, light-protected container; avoid freeze-thaw cycles and moisture (Sigma-Aldrich Guidelines) Once reconstituted, the solution should be refrigerated at 2-8°C and used within 28 days.

Peptide.co’s CJC-1295 No DAC has been verified at 99.9% purity through independent third-party HPLC testing. The current batch (Lot #YPB.219, 10mg) includes a full Certificate of Analysis confirming identity, purity, and peptide content. All COAs are publicly available at coa.peptide.co. Testing covers HPLC purity analysis, mass spectrometry identity confirmation, heavy metals screening (<20 ppb), and microbial limits (TAMC/TYMC: 0 CFU). All products are manufactured in FDA-registered facilities in the United States.

Synthetic analog of GHRH (1-29); binds to GHRH receptors (GHRHR) on anterior pituitary somatotroph cells, activating Gs-protein/cAMP pathway to stimulate pulsatile GH secretion (Wikipedia Mod GRF); BOC Sciences) These mechanisms have been characterized in preclinical models only.

CJC-1295 No DAC is supplied as a lyophilized (freeze-dried) powder and must be reconstituted before use in research applications. The standard reconstitution solvent is bacteriostatic water (sterile water containing 0.9% benzyl alcohol). When reconstituting, direct the solvent gently along the inside wall of the vial — do not spray directly onto the lyophilized powder. Allow the peptide to dissolve naturally without shaking or vortexing. For detailed reconstitution volume calculations, use the free Bacteriostatic Water Calculator or Peptide Reconstitution Calculator on Peptide.co.