(10β,12α,17α,23α,24ξ,25α,30ξ,35α,36ξ,40ξ,41ξ,42R)-30,35,40-tris(2-carbamoylethyl)-24,36,41-tris(carbamoylmethyl)-46-hydroxy-12-(hydroxymethyl)-1,5,6,17,23,28,31,31,36,38,41,42-dodecamethyl-15,20-dioxo-11,14,16-trioxa-2λ⁵,9,19,26,43λ⁵,44λ⁵,45λ⁵-heptaaza-15λ⁵-phospha-1-cobaltadodecacyclo(27.14.1.¹¹,³⁴.¹²,⁹.¹¹⁰,¹³.0¹,²⁶.0³,⁸.0²³,²⁷.0²⁵,⁴².0³²,⁴⁴.0³⁹,⁴³.

Nerve regeneration and conduction in sciatic nerve injury, acrylamide neuropathy, diabetic neuropathy rat models Neural Plast. 2013; neuroprotection against glutamate toxicity, optic nerve crush Int J Biochem Cell Biol. 2004; ALS mouse models (wobbler mice); pain modulation in chronic compression DRG rats; teratogenic protection in chick embryos Sci Rep. All findings referenced are from preclinical and in vitro studies. No approved clinical applications exist for this research compound.

-20°C, protect from light, store desiccated (dry) Sigma-Aldrich Avoid repeated freeze-thaw cycles. Once reconstituted, the solution should be refrigerated at 2-8°C and used within 28 days.

Peptide.co’s B12 has been verified at 99.8% purity through independent third-party HPLC testing. The current batch (Lot #YPB.251, 10ml) includes a full Certificate of Analysis confirming identity, purity, and peptide content. All COAs are publicly available at coa.peptide.co. Testing covers HPLC purity analysis, mass spectrometry identity confirmation, heavy metals screening (<20 ppb), and microbial limits (TAMC/TYMC: 0 CFU). All products are manufactured in FDA-registered facilities in the United States.

Cofactor for methionine synthase in homocysteine-to-methionine conversion (methylation cycle); promotes myelin synthesis/regeneration, Schwann cell mitosis, axonal sprouting; inhibits ectopic spontaneous discharges in injured sensory neurons; antagonizes glutamate neurotoxicity; activates Erk1/2 and Akt signaling Neural Plast. 2013 These mechanisms have been characterized in preclinical models only.

B12 should be handled using standard laboratory safety protocols. Use appropriate personal protective equipment including gloves and eye protection. Work in a clean environment to prevent contamination. Follow your institution’s guidelines for handling research compounds. Refer to the Safety Data Sheet (SDS) for detailed handling instructions.