ARA-290, also known as Cibinetide, is an 11-amino acid synthetic peptide derived from the structure of erythropoietin (EPO). CAS Number: 1208243-50-8. Molecular weight: 1257.4 Da. It selectively targets the innate repair receptor (IRR), a heteromer of the EPO receptor and the beta common receptor, without stimulating erythropoiesis.

Preclinical studies in diet-induced insulin resistance (Br J Pharmacol 2014), diabetic retinopathy (Diabetes 2011), diabetic autonomic neuropathy (Exp Neurol 2011), myocardial infarction (Mol Med 2011), chronic heart failure (J Pharmacol Exp Ther 2013), burns (PNAS 2013), traumatic brain injury (J Neurotrauma 2013), shock-induced multi-organ failure (Mol Med 2011), neuropathic pain (Mol Pain 2014). All findings referenced are from preclinical and in vitro studies. No approved clinical applications exist for this research compound.

Store lyophilized powder at -20°C or -80°C, protected from light and moisture Avoid repeated freeze-thaw cycles. Once reconstituted, the solution should be refrigerated at 2-8°C and used within 28 days.

Peptide.co’s ARA-290 has been verified at 99.4% purity through independent third-party HPLC testing. The current batch (Lot #YPB.277, 10mg) includes a full Certificate of Analysis confirming identity, purity, and peptide content. All COAs are publicly available at coa.peptide.co. Testing covers HPLC purity analysis, mass spectrometry identity confirmation, heavy metals screening (<20 ppb), and microbial limits (TAMC/TYMC: 0 CFU). All products are manufactured in FDA-registered facilities in the United States.

Selectively binds innate repair receptor (IRR; heterocomplex of EPO receptor and β-common receptor CD131), activating tissue protection, anti-inflammation, and repair pathways without erythropoietic effects; suppresses proinflammatory cytokines (TNF-α, IL-6), microglia activation These mechanisms have been characterized in preclinical models only.

ARA-290 is supplied as a lyophilized (freeze-dried) powder and must be reconstituted before use in research applications. The standard reconstitution solvent is bacteriostatic water (sterile water containing 0.9% benzyl alcohol). When reconstituting, direct the solvent gently along the inside wall of the vial — do not spray directly onto the lyophilized powder. Allow the peptide to dissolve naturally without shaking or vortexing. For detailed reconstitution volume calculations, use the free Bacteriostatic Water Calculator or Peptide Reconstitution Calculator on Peptide.co.