1-methylquinolin-1-ium-5-amine, also known as 5-Amino-1-methylquinolinium, 5-amino-1MQ, NNMTi, is a small molecule research compound. CAS Number: 42464-96-0 (for iodide salt). Molecular weight: 159.21 Da.

NNMT inhibition in adipocytes and reversal of high-fat diet-induced obesity in mice; suppression of lipogenesis and adipogenesis in 3T3-L1 pre-adipocytes and adipocytes Biochemical Pharmacology (PMC5826726) All findings referenced are from preclinical and in vitro studies. No approved clinical applications exist for this research compound.

−20°C, dry and protected from light Sigma-Aldrich; standard for lyophilized research compounds Sigma Peptide Protocol Avoid repeated freeze-thaw cycles. Once reconstituted, the solution should be refrigerated at 2-8°C and used within 28 days.

Every batch of 5-Amino-1mq from Peptide.co undergoes independent third-party HPLC testing. Current verified batches: 5mg batch (Lot #YPB.242): 99.1% purity; 50mg batch (Lot #YPB.247): 99.2% purity. Full Certificates of Analysis are publicly available at coa.peptide.co, covering HPLC purity, mass spectrometry identity confirmation, heavy metals screening (<20 ppb), and microbial limits (TAMC/TYMC: 0 CFU). All products are manufactured in FDA-registered facilities in the United States.

Selective inhibitor of nicotinamide N-methyltransferase (NNMT), reduces intracellular 1-methylnicotinamide (1-MNA), increases NAD⁺ and SAM levels, shunts nicotinamide into NAD⁺ salvage pathway Biochemical Pharmacology (PMC5826726) These mechanisms have been characterized in preclinical models only.

5-Amino-1mq should be handled using standard laboratory safety protocols. Use appropriate personal protective equipment including gloves and eye protection. Work in a clean environment to prevent contamination. Follow your institution’s guidelines for handling research compounds. Refer to the Safety Data Sheet (SDS) for detailed handling instructions.